Format

Send to

Choose Destination
Stroke. 2008 Oct;39(10):2902-9. doi: 10.1161/STROKEAHA.107.511261. Epub 2008 Jul 24.

Blood biomarkers in the diagnosis of ischemic stroke: a systematic review.

Author information

1
Division of Clinical Neurosciences, University of Edinburgh, UK. william.whiteley@ed.ac.uk

Abstract

BACKGROUND AND PURPOSE:

The diagnosis of ischemic stroke can be difficult. CT may be normal in the early stages of ischemic stroke or in patients with minor symptoms and MR is not always possible. Many blood markers have been proposed for the diagnosis of stroke in the acute setting.

METHODS:

We have systematically reviewed the diagnostic literature and found 21 studies testing 58 single biomarkers and 7 panels of several biomarkers. Although all show either a high sensitivity or specificity, there are limitations in the design and reporting of all the studies that mean no biomarker can be recommended for use in clinical practice.

CONCLUSIONS:

We make recommendations for the design and reporting of studies of diagnostic blood biomarkers in stroke.

PMID:
18658039
DOI:
10.1161/STROKEAHA.107.511261
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Health
Loading ...
Support Center