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J Biomed Opt. 2008 May-Jun;13(3):030505. doi: 10.1117/1.2937470.

Quantification of cardiac fiber orientation using optical coherence tomography.

Author information

1
Case Western Reserve University, Biomedical Engineering Department, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA. cfleming@case.edu

Abstract

Heterogeneity in cardiac tissue microstructure is a potential mechanism for the generation and maintenance of arrhythmias. Abnormal changes in fiber orientation increase the likelihood of arrhythmia. We present optical coherence tomography (OCT) as a method to image myofibers in excised intact heart preparations. Three-dimensional (3-D) image sets were gathered from the rabbit right ventricular free wall (RVFW) using a microscope-integrated OCT system. An automated algorithm for fiber orientation quantification in the plane parallel to the wall surface was developed. The algorithm was validated by comparison with manual measurements. Quantifying fiber orientation in the plane parallel to the wall surface from OCT images can be used to help understand the conduction system of the specific sample being imaged.

PMID:
18601522
PMCID:
PMC2714642
DOI:
10.1117/1.2937470
[Indexed for MEDLINE]
Free PMC Article

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