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Trends Cardiovasc Med. 2008 Apr;18(3):93-8. doi: 10.1016/j.tcm.2008.01.004.

Understanding proteasome assembly and regulation: importance to cardiovascular medicine.

Author information

1
Department of Physiology, Medicine/Division of Cardiology, David Geffen School of Medicine at UCLA, University of California-Los Angeles, CA 90095, USA.

Abstract

The cardiac proteasome is increasingly recognized as a complex, heterogeneous, and dynamic organelle contributing to the modulation of cardiac function in health and diseases. The emerging picture of the proteasome system reveals a highly regulated and organized molecular machine integrated into multiple biologic processes of the cell. Full appreciation of its cardiovascular relevance requires an understanding of its proteolytic function as well as its underlying regulatory mechanisms, of which assembly, stoichiometry, posttranslational modification, and the role of the associating partners are increasingly poignant.

PMID:
18436147
PMCID:
PMC2441911
DOI:
10.1016/j.tcm.2008.01.004
[Indexed for MEDLINE]
Free PMC Article

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