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Pharm World Sci. 2008 Aug;30(4):316-8. doi: 10.1007/s11096-008-9204-9. Epub 2008 Apr 4.

Interaction between methotrexate and omeprazole in an adolescent with leukemia: a case report.

Author information

1
Department of Pharmacy, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. tiene.bauters@uzgent.be

Abstract

We present a case of severe mucositis due to a drug-drug interaction between methotrexate (MTX) and omeprazole in an adolescent with Acute Lymphatic Leukemia (ALL). In view of the prevalence of MTX in many cytotoxic protocols, and the frequent use of omeprazole in the (ambulatory) oncology setting, we believe that this case-report is worth mentioning.

PMID:
18386155
DOI:
10.1007/s11096-008-9204-9
[Indexed for MEDLINE]

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