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Nature. 2008 Jan 24;451(7177):417-24. doi: 10.1038/nature06485.

Catalytic C-H functionalization by metal carbenoid and nitrenoid insertion.

Author information

1
Department of Chemistry, University at Buffalo, the State University of New York, Buffalo, New York 14260-3000, USA. hdavies@buffalo.edu

Abstract

Novel reactions that can selectively functionalize carbon-hydrogen bonds are of intense interest to the chemical community because they offer new strategic approaches for synthesis. A very promising 'carbon-hydrogen functionalization' method involves the insertion of metal carbenes and nitrenes into C-H bonds. This area has experienced considerable growth in the past decade, particularly in the area of enantioselective intermolecular reactions. Here we discuss several facets of these kinds of C-H functionalization reactions and provide a perspective on how this methodology has affected the synthesis of complex natural products and potential pharmaceutical agents.

PMID:
18216847
PMCID:
PMC3033428
DOI:
10.1038/nature06485
[Indexed for MEDLINE]
Free PMC Article

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