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Cell. 2007 Oct 5;131(1):17-9.

How to assemble a capsid.

Author information

1
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. wes@biochem.utah.edu

Abstract

Retroviral capsids are composed of hexagonal arrays of the viral CA protein. In this issue of Cell, Ganser-Pornillos et al. (2007) provide a molecular model of the hexagonal HIV-1 CA lattice obtained from a new electron cryomicroscopic reconstruction. This study reveals the three principal stabilizing interfaces in the capsid lattice and explains how two different classes of inhibitors can block capsid assembly.

PMID:
17923081
DOI:
10.1016/j.cell.2007.09.028
[Indexed for MEDLINE]
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