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Pacing Clin Electrophysiol. 2007 Oct;30(10):1294-8.

Brugada syndrome unmasked by accidental inhalation of gasoline vapors.

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Department of Cardiology, University Hospital Dubrava, Zagreb, Croatia.


Loss-of-function mutations in the gene SCN5A can cause Brugada syndrome (BrS), which is an inherited form of idiopathic ventricular fibrillation. We report the case of a 46-year-old patient, with no previous medical history, who had ventricular fibrillation after accidental inhalation of gasoline vapors. His electrocardiogram (ECG) showed a typical type-1 BrS pattern that persisted after the acute event. Genetic investigations allowed the identification of a novel SCN5A mutation leading to a frame-shift and early termination of the channel protein. Biochemical and cellular electrophysiology experiments confirmed the loss-of-function of the mutant allele. The patient was implanted with a cardioverter/defibrillator.

[Indexed for MEDLINE]

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