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J Comput Assist Tomogr. 2007 Sep-Oct;31(5):666-70.

Proton magnetic resonance spectroscopy of the hippocampus in patients with mild cognitive impairment: a pilot study.

Author information

1
Departments of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. mfranczak@neuroscience.mcw.edu

Abstract

OBJECTIVE:

To assess the brain metabolites in the hippocampus of patients with mild cognitive impairment (MCI) using proton magnetic resonance spectroscopy at 0.5 T.

METHODS:

Absolute concentrations and ratios to creatine of N-acetyl aspartate, myoinositol, glutamate + glutamine, and choline were measured in the right and left hippocampus of 5 MCI patients and 5 control subjects.

RESULTS:

In MCI subjects, reduced N-acetyl aspartate was found in the right hippocampus (P = 0.01), and increased myoinositol was found in the left hippocampus (P = 0.02). Myoinositol/N-acetyl aspartate ratios were higher in the right (P = 0.03) and left (P = 0.01) hippocampus of MCI subjects. No significant difference in the concentration of glutamate + glutamine was observed between the control and MCI groups.

CONCLUSIONS:

An increase in myoinositol and a decrease in N-acetyl aspartate may be observed in the preclinical stages of dementia. Ratio measurements of these metabolites may serve as a biomarker for MCI.

PMID:
17895774
DOI:
10.1097/RCT.0b013e318031bc31
[Indexed for MEDLINE]
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