Format

Send to

Choose Destination
J Biomed Opt. 2007 Jul-Aug;12(4):044019.

Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart.

Author information

1
Washington University in Saint Louis, Department of Biomedical Engineering, Saint Louis, Missouri 63130-4899, USA.

Abstract

Cardiac fluorescent optical imaging provides the unique opportunity to investigate the dynamics of propagating electrical waves during ventricular arrhythmias and the termination of arrhythmias by strong electric shocks. Panoramic imaging systems using charge-coupled device (CCD) cameras as the photodetector have been developed to overcome the inability to monitor electrical activity from the entire cardiac surface. Photodiode arrays (PDAs) are known to have higher temporal resolution and signal quality, but lower spatial resolution compared to CCD cameras. We construct a panoramic imaging system with three PDAs and image Langendorff perfused rabbit hearts (n=18) during normal sinus rhythm, epicardial pacing, and arrhythmias. The recorded spatiotemporal dynamics of electrical activity is texture mapped onto a reconstructed 3-D geometrical heart model specific to each heart studied. The PDA-based system provides sufficient spatial resolution (1.72 mm without interpolation) for the study of wavefront propagation in the rabbit heart. The reconstructed 3-D electrical activity provides us with a powerful tool to investigate the fundamental mechanisms of arrhythmia maintenance and termination.

PMID:
17867823
DOI:
10.1117/1.2753748
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center