Prophylaxis of hemicrania continua: two new cases effectively treated with topiramate

Headache. 2007 Mar;47(3):441-3. doi: 10.1111/j.1526-4610.2007.00733.x.

Abstract

Hemicrania continua (HC) is an uncommon and under-recognized primary headache disorder characterized by a strictly unilateral continuous headache of moderate intensity with possible exacerbations and associated with ipsilateral autonomic features. HC has generally a prompt and enduring response to indomethacin although 25% to 50% of treated patients develop gastrointestinal side effects. These cases pose a difficult management challenge as no other drug is consistently effective in HC. Recently 2 HC patients responsive to topiramate treatment have been reported. Here we describe 2 more patients effectively treated with topiramate. Neither reported any side effects and one had persisting response for 6 months after drug withdrawal.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Anticonvulsants / therapeutic use*
  • Female
  • Fructose / analogs & derivatives*
  • Fructose / therapeutic use
  • Gastritis / chemically induced
  • Headache / prevention & control*
  • Humans
  • Indomethacin / adverse effects
  • Indomethacin / therapeutic use
  • Middle Aged
  • Retreatment
  • Topiramate

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticonvulsants
  • Topiramate
  • Fructose
  • Indomethacin