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J Med Chem. 2007 Feb 22;50(4):776-81.

Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase.

Author information

1
Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, California 94080, USA.

Abstract

The design and synthesis of a novel series of potent and cell permeable peptidomimetic inhibitors of the human beta-secretase (BACE) are described. These inhibitors feature a hydroxyethyl secondary amine isostere and a novel aromatic ring replacement for the C-terminus. The crystal structure of BACE in complex with this hydroxyethyl secondary amine isostere inhibitor is also presented.

PMID:
17300163
DOI:
10.1021/jm061242y
[Indexed for MEDLINE]

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