Format

Send to

Choose Destination
See comment in PubMed Commons below
Rheumatology (Oxford). 2007 May;46(5):830-2. Epub 2007 Jan 25.

Hodgkin's lymphoma in systemic lupus erythematosus.

Author information

  • 1Division of Clinical Epidemiology, Montreal General Hospital, Montreal, QC, Canada. sasha.bernatsky@mail.mcgill.ca

Abstract

OBJECTIVE:

In systemic lupus erythematosus (SLE), there is a well-documented increased risk of non-Hodgkin's lymphoma (NHL), but little is known about the risk of Hodgkin's lymphoma (HL). The purpose of our work was to describe the phenomenon of HL in SLE.

METHODS:

A multi-site cohort of 9547 SLE subjects was assembled; HL cases were ascertained through cancer registry linkage, and the standardized incidence ratio (SIR) for HL was determined. We also performed a literature search for HL cases in SLE, and compared these with our sample. Finally, we pooled results from our cohort study with two large population-based cohort studies providing SIR estimates for HL in SLE.

RESULTS:

Five cases of HL occurred in our SLE cohort during the observation interval, for an SIR of 2.4 (95% CI 0.8, 5.5). The literature review documented 13 HL case reports developing in patients with SLE. A pooled analysis combining our data with the other large cohort studies yielded a standardized incidence ratio of 3.16 (95% CI, 1.63-5.51) for HL in SLE.

CONCLUSIONS:

Data suggest that risk in SLE is increased not only for NHL, but also for other malignancies arising from B-lymphocytes, including HL.

PMID:
17255135
DOI:
10.1093/rheumatology/kel444
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center