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Cardiovasc Drugs Ther. 2006 Dec;20(6):425-32.

Mitochondrial permeability transition in cardiac cell injury and death.

Author information

1
Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095-1679, USA. hhonda@mednet.ucla.edu

Abstract

Mitochondria can serve as the arbiter of cell fate in response to stress. Mitochondrial permeability transition (MPT) is characterized by permeabilization of an otherwise relatively impermeable mitochondrial inner membrane and appears to have a major role in ischemia/reperfusion (I/R) injury in myocardial infarction and stroke. After I/R, the fate of the cell is determined by the extent of MPT. If minimal, the cell may recover; if moderate, the cell may undergo programmed cell death; if severe, the cell may die from necrosis due to inadequate energy production. After reviewing the role of MPT in disease, we examine the signaling and metabolic networks that regulate MPT. We then conclude with some of the challenges in future MPT research.

PMID:
17171295
DOI:
10.1007/s10557-006-0642-0
[Indexed for MEDLINE]

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