Atorvastatin therapy associated with improvement in left ventricular remodeling in a case of idiopathic dilated cardiomyopathy

Am J Med Sci. 2006 Dec;332(6):361-3. doi: 10.1097/00000441-200612000-00011.

Abstract

Statins have pleiotropic effects such as anti-inflammatory and vascular protective effects that would be beneficial for patients with chronic heart failure. This report describes a patient with idiopathic dilated cardiomyopathy and a long-standing history of heart failure that was treated with atorvastatin in addition to conventional therapy that included beta-blockers. Atorvastatin therapy for 12 months was associated with an improvement in cardiac function and improved left ventricular remodeling and peak oxygen consumption. This result suggests that statin therapy may be a potential novel treatment strategy for patients with chronic heart failure.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticholesteremic Agents / therapeutic use
  • Atorvastatin
  • Cardiomyopathy, Dilated / drug therapy*
  • Cardiovascular Agents / therapeutic use*
  • Heptanoic Acids / pharmacology*
  • Heptanoic Acids / therapeutic use*
  • Humans
  • Hypercholesterolemia / drug therapy
  • Male
  • Pyrroles / pharmacology*
  • Pyrroles / therapeutic use*
  • Ventricular Remodeling / drug effects*

Substances

  • Anticholesteremic Agents
  • Cardiovascular Agents
  • Heptanoic Acids
  • Pyrroles
  • Atorvastatin