Sweet's syndrome in chronic lymphocytic leukemia associated with neutropenic fever and granulocyte colony stimulation factor

Am J Hematol. 2006 Sep;81(9):703-5. doi: 10.1002/ajh.20666.

Abstract

Granulocyte colony stimulation factor (G-CSF) is commonly used in the treatment of chemotherapy-induced myelosuppression. We report the case of a 62-year-old man with chronic lymphocytic leukemia who presented with neutropenic fever and sepsis. After treatment with G-CSF he developed Sweet's syndrome. Sweet's syndrome is a rare disorder but has been associated with cancer recurrence as well as administration of G-CSF. We present clinical and pathologic images that highlight the salient features of this entity.

Publication types

  • Case Reports

MeSH terms

  • Fatal Outcome
  • Fever / blood
  • Fever / complications
  • Fever / drug therapy*
  • Granulocyte Colony-Stimulating Factor* / administration & dosage
  • Granulocyte Colony-Stimulating Factor* / adverse effects
  • Granulocyte Colony-Stimulating Factor* / therapeutic use
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / blood
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
  • Male
  • Middle Aged
  • Neutrophil Infiltration*
  • Recombinant Proteins
  • Skin / pathology
  • Sweet Syndrome / chemically induced*
  • Sweet Syndrome / pathology

Substances

  • Recombinant Proteins
  • Granulocyte Colony-Stimulating Factor