Abstract
Granulocyte colony stimulation factor (G-CSF) is commonly used in the treatment of chemotherapy-induced myelosuppression. We report the case of a 62-year-old man with chronic lymphocytic leukemia who presented with neutropenic fever and sepsis. After treatment with G-CSF he developed Sweet's syndrome. Sweet's syndrome is a rare disorder but has been associated with cancer recurrence as well as administration of G-CSF. We present clinical and pathologic images that highlight the salient features of this entity.
(c) 2006 Wiley-Liss, Inc.
MeSH terms
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Fatal Outcome
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Fever / blood
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Fever / complications
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Fever / drug therapy*
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Granulocyte Colony-Stimulating Factor* / administration & dosage
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Granulocyte Colony-Stimulating Factor* / adverse effects
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Granulocyte Colony-Stimulating Factor* / therapeutic use
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell / blood
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Leukemia, Lymphocytic, Chronic, B-Cell / complications
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Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
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Male
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Middle Aged
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Neutrophil Infiltration*
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Recombinant Proteins
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Skin / pathology
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Sweet Syndrome / chemically induced*
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Sweet Syndrome / pathology
Substances
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Recombinant Proteins
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Granulocyte Colony-Stimulating Factor