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Science. 2005 Dec 16;310(5755):1809-13.

Long-term modulation of electrical synapses in the mammalian thalamus.

Author information

1
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA. Carole_Landisman@hms.harvard.edu

Abstract

Electrical synapses are common between inhibitory neurons in the mammalian thalamus and neocortex. Synaptic modulation, which allows flexibility of communication between neurons, has been studied extensively at chemical synapses, but modulation of electrical synapses in the mammalian brain has barely been examined. We found that the activation of metabotropic glutamate receptors, via endogenous neurotransmitter or by agonist, causes long-term reduction of electrical synapse strength between the inhibitory neurons of the rat thalamic reticular nucleus.

PMID:
16357260
DOI:
10.1126/science.1114655
[Indexed for MEDLINE]
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