The relative levels of cyclin D1a and D1b alternative transcripts in mantle cell lymphoma may depend more on sample origin than on CCND1 polymorphism

Haematologica. 2005 Jun;90(6):854-6.

Abstract

The relative levels of cyclin D1 (CCND1) (a) and (b) transcripts were determined by real-time reverse transcription polymerase chain reaction (RT-PCR) and found to vary according to the tissue origin in both control and tumor samples. A five-fold overexpression of both isoforms was observed in 28/38 cases of mantle cell lymphoma (MCL) and of only one isoform in 10/38 MCL. No correlation was observed between expression of cyclin D1 isoforms and CCND1 genotype at position 870.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing*
  • Cyclin D1 / biosynthesis*
  • Cyclin D1 / genetics*
  • Gene Expression Regulation, Neoplastic*
  • Genotype
  • Humans
  • Leukocytes, Mononuclear / metabolism
  • Lymphoma, Mantle-Cell / genetics*
  • Lymphoma, Mantle-Cell / metabolism*
  • Polymorphism, Genetic*
  • Protein Isoforms
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • Protein Isoforms
  • Cyclin D1