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Bioorg Med Chem Lett. 2005 May 2;15(9):2275-8.

Oximinoarylsulfonamides as potent HIV protease inhibitors.

Author information

1
Abbott Laboratories, GPRD, D-47D, Building AP52N, 200 Abbott Park Road, Abbott Park, IL 60064-3501, USA. clinton.yeung@abbott.com

Abstract

The need for a potent HIV protease inhibitor (PI) to combat emerging PI-resistant viruses is anticipated. Analogs formulated from the combination of structural fragments of Ritonavir, Lopinavir, and Amprenavir were synthesized. Analogs containing the oxime pharmacophore were found to have improved activities against both wild type and resistant (A17) viruses. The synthesis and structure-activity relationships (SAR) based upon the in vitro IC50 of this series of compounds are reported.

PMID:
15837308
DOI:
10.1016/j.bmcl.2005.03.008
[Indexed for MEDLINE]

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