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Antimicrob Agents Chemother. 2005 Feb;49(2):853-6.

Modeling in vivo pharmacokinetics and pharmacodynamics of moxifloxacin therapy for Mycobacterium tuberculosis infection by using a novel cartridge system.

Author information

1
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Abstract

To study the efficacy of moxifloxacin treatment for tuberculosis, we utilized a novel cartridge system to simulate in vivo pharmacokinetics. We found this system to be a robust method for modeling in vivo pharmacokinetics and present data supporting the utility of intermittent moxifloxacin treatment as a component of antituberculosis chemotherapy.

PMID:
15673788
PMCID:
PMC547230
DOI:
10.1128/AAC.49.2.853-856.2005
[Indexed for MEDLINE]
Free PMC Article

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