1. Science. 2005 Jan 14;307(5707):258-62.

Anticonvulsant medications extend worm life-span.

Evason K(1), Huang C, Yamben I, Covey DF, Kornfeld K.

Author information: 
(1)Department of Molecular Biology and Pharmacology, Washington University School
of Medicine, St. Louis, MO 63110, USA.

Comment in
    Science. 2005 Jan 14;307(5707):193.

Genetic studies have elucidated mechanisms that regulate aging, but there has
been little progress in identifying drugs that delay aging. Here, we report that 
ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and
maximum life-span of Caenorhabditis elegans and delay age-related declines of
physiological processes, indicating that these compounds retard the aging
process. These compounds, two of which are approved for human use, are
anticonvulsants that modulate neural activity. These compounds also regulated
neuromuscular activity in nematodes. These findings suggest that the
life-span-extending activity of these compounds is related to the anticonvulsant 
activity and implicate neural activity in the regulation of aging.

DOI: 10.1126/science.1105299 
PMID: 15653505  [Indexed for MEDLINE]