Interaction of bismuth subsalicylate with fruit juices, ascorbic acid, and thiol-containing substrates to produce soluble bismuth products active against Clostridium difficile

Antimicrob Agents Chemother. 2005 Jan;49(1):431-3. doi: 10.1128/AAC.49.1.431-433.2005.

Abstract

Bismuth subsalicylate (BSS), the active ingredient of Pepto-Bismol, has been used for many years to treat various disorders of the gastrointestinal tract. Using mass spectrometry and the agar dilution method, we determined that insoluble BSS interacts with certain dietary components and organic substrates to produce water-soluble products with activity against Clostridium difficile.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Ascorbic Acid / chemistry*
  • Ascorbic Acid / pharmacology
  • Beverages
  • Bismuth / chemistry
  • Bismuth / pharmacology*
  • Clostridioides difficile / drug effects*
  • Drug Interactions
  • Fruit*
  • Humans
  • Microbial Sensitivity Tests
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacology*
  • Salicylates / chemistry
  • Salicylates / pharmacology*
  • Sulfhydryl Compounds / chemistry*
  • Sulfhydryl Compounds / pharmacology

Substances

  • Anti-Bacterial Agents
  • Organometallic Compounds
  • Salicylates
  • Sulfhydryl Compounds
  • bismuth subsalicylate
  • Ascorbic Acid
  • Bismuth