[Distribution of IgG subclass of anti-myeloperoxidase antibodies in sera from patients with propylthiouracil induced vasculitis]

Zhonghua Yi Xue Za Zhi. 2004 Oct 2;84(19):1625-8.
[Article in Chinese]

Abstract

Objective: To investigate the distribution of IgG subclass of anti-myeloperoxidase (MPO) antibodies, a kind of antineutrophil cytoplasmic autoantibody (ANCA), in sera from patients with propylthiouracil (PIU)-induced vasculitis.

Methods: Serum samples were collected from 12 patients with PIU-induced MPO ANCA positive vasculitis, both sera of active and remission phases were collected from 10 of which, and only serum of active phase was collected from 2 of which. Anti-MPO IgG subclasses were detected by antigen-specific ELISA. The distribution of anti-MPO IgG subclasses in PIU-induced vasculitis was compared with that in primary vasculitis.

Results: Anti-MPO IgG3 subclass was not detected in the sera from both active and remission phases of PIU-induced vasculitis. In the active phase the following anti-MPO IgG subclasses were found: IgG1 (12/12, 100%), IgG2 (1/12, 66.7%), and IgG4 (7/12, 58.3%). In the remission phase, the following anti-MPO IgG subclasses were found: IgG1 (9/10, 90%), IgG2 (4/10, 40%), and IgG4 (2/10, 20%). The titer of anti-MPO IgG4 subclass remained high in the remission phase in primary vasculitis; however, it decreased significantly after the cessation of PIU use in PIU-induced vasculitis.

Conclusion: The distribution of anti-MPO IgG subclasses in the sera of the patients with PIU-induced vasculitis is different from that of the patients with primary vasculitis. The higher titer pf MPO-ANCA in the sera of the patients with PIU-induced vasculitis may be associated with the repeated PIU stimulation.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Antineutrophil Cytoplasmic / blood*
  • Antibodies, Antineutrophil Cytoplasmic / classification
  • Child
  • Female
  • Humans
  • Immunoglobulin G / blood*
  • Immunoglobulin G / classification
  • Male
  • Middle Aged
  • Propylthiouracil
  • Vasculitis / blood*
  • Vasculitis / chemically induced

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Immunoglobulin G
  • Propylthiouracil