Objective: To study the effect and mechanism of Luohuo capsule (LHC) in treating essential hypertension of Phlegm-stasis blocking Collateral type.
Methods: Ninety patients were randomly divided into two groups, the 60 patients in the treated group treated with LHC, and the 30 patients in the control group treated with Beijing Hypotension No. 0, the therapeutic course for both groups were 4 weeks. The changes of blood pressure, clinical symptoms, hemorrheologic parameters, plasma endothelin (ET), angiotensin II (Ang II), nitric oxide (NO) level before and after treatment were observed.
Results: The total effective rate of clinical symptoms in the treated and the control group was 83.3% and 70.0% respectively, with no significant difference between them, but the degree of systolic pressure reducing in the former were better than those in the latter (P<0.05). The levels of hemorrheological parameters, plasma NO, ET and Ang II in the treated group were all improved (P<0.01 or P<0.05), but in the control group, improvement only showed in part of the hemorrheological parameters, ET and Ang II levels.
Conclusion: LHC has quite a promising effect in treating essential hypertension of Phlegm-stasis blocking Collateral type, the mechanism might be related with the improvement of hemorrheological parameters, increasing blood NO level and decreasing ET and Ang II levels.