Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya

Trans R Soc Trop Med Hyg. 2003 Sep-Oct;97(5):513-4. doi: 10.1016/s0035-9203(03)80010-x.

Abstract

Sickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1% in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Altitude
  • Child
  • Child, Preschool
  • Endemic Diseases
  • Glucosephosphate Dehydrogenase Deficiency / epidemiology*
  • Glucosephosphate Dehydrogenase Deficiency / genetics
  • Hemoglobin, Sickle / genetics
  • Humans
  • Infant
  • Infant, Newborn
  • Kenya / epidemiology
  • Malaria, Falciparum / epidemiology*
  • Malaria, Falciparum / genetics
  • Middle Aged
  • Polymorphism, Genetic
  • Prevalence
  • Residence Characteristics
  • Sickle Cell Trait / epidemiology*
  • Sickle Cell Trait / genetics

Substances

  • Hemoglobin, Sickle
  • hemoglobin AS