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Items: 1 to 20 of 23


Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor.

Grewal PK, Aziz PV, Uchiyama S, Rubio GR, Lardone RD, Le D, Varki NM, Nizet V, Marth JD.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20218-23. doi: 10.1073/pnas.1313905110. Epub 2013 Nov 27.


Computational modeling of glucose transport in pancreatic β-cells identifies metabolic thresholds and therapeutic targets in diabetes.

Luni C, Marth JD, Doyle FJ 3rd.

PLoS One. 2012;7(12):e53130. doi: 10.1371/journal.pone.0053130. Epub 2012 Dec 27.


Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport.

Ohtsubo K, Chen MZ, Olefsky JM, Marth JD.

Nat Med. 2011 Aug 14;17(9):1067-75. doi: 10.1038/nm.2414.


Mammalian glycosylation in immunity.

Marth JD, Grewal PK.

Nat Rev Immunol. 2008 Nov;8(11):874-87. doi: 10.1038/nri2417. Review.


A unified vision of the building blocks of life.

Marth JD.

Nat Cell Biol. 2008 Sep;10(9):1015-6. doi: 10.1038/ncb0908-1015. No abstract available.


The Ashwell receptor mitigates the lethal coagulopathy of sepsis.

Grewal PK, Uchiyama S, Ditto D, Varki N, Le DT, Nizet V, Marth JD.

Nat Med. 2008 Jun;14(6):648-55. doi: 10.1038/nm1760. Epub 2008 May 18.


Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis.

Green RS, Stone EL, Tenno M, Lehtonen E, Farquhar MG, Marth JD.

Immunity. 2007 Aug;27(2):308-20. Epub 2007 Aug 2.


Conditional mutagenesis of the genome using site-specific DNA recombination.

Ohtsubo K, Marth JD.

CSH Protoc. 2007 Jul 1;2007:pdb.top12. doi: 10.1101/pdb.top12.


Glycosylation in cellular mechanisms of health and disease.

Ohtsubo K, Marth JD.

Cell. 2006 Sep 8;126(5):855-67. Review.


Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes.

Ohtsubo K, Takamatsu S, Minowa MT, Yoshida A, Takeuchi M, Marth JD.

Cell. 2005 Dec 29;123(7):1307-21.


A genetic approach to Mammalian glycan function.

Lowe JB, Marth JD.

Annu Rev Biochem. 2003;72:643-91. Epub 2003 Mar 27. Review.


Genetic remodeling of protein glycosylation in vivo induces autoimmune disease.

Chui D, Sellakumar G, Green R, Sutton-Smith M, McQuistan T, Marek K, Morris H, Dell A, Marth J.

Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1142-7.


The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis.

Priatel JJ, Chui D, Hiraoka N, Simmons CJ, Richardson KB, Page DM, Fukuda M, Varki NM, Marth JD.

Immunity. 2000 Mar;12(3):273-83.


The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.

Shafi R, Iyer SP, Ellies LG, O'Donnell N, Marek KW, Chui D, Hart GW, Marth JD.

Proc Natl Acad Sci U S A. 2000 May 23;97(11):5735-9.


Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation.

Ellies LG, Tsuboi S, Petryniak B, Lowe JB, Fukuda M, Marth JD.

Immunity. 1998 Dec;9(6):881-90.


Immune regulation by the ST6Gal sialyltransferase.

Hennet T, Chui D, Paulson JC, Marth JD.

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4504-9.


Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis.

Chui D, Oh-Eda M, Liao YF, Panneerselvam K, Lal A, Marek KW, Freeze HH, Moremen KW, Fukuda MN, Marth JD.

Cell. 1997 Jul 11;90(1):157-67.


Recent advances in gene mutagenesis by site-directed recombination.

Marth JD.

J Clin Invest. 1996 May 1;97(9):1999-2002. Review. No abstract available.


T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination.

Hennet T, Hagen FK, Tabak LA, Marth JD.

Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12070-4.


Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K.

Science. 1994 Jul 1;265(5168):103-6.


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