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Infect Immun. 2003 Dec;71(12):7170-2.

Deletion of Mycobacterium tuberculosis sigma factor E results in delayed time to death with bacterial persistence in the lungs of aerosol-infected mice.

Author information

1
Department of Medicine, Center for Tuberculosis Research, Johns Hopkins School of Medicine, Baltimore, Maryland 21231-1001, USA.

Abstract

The stress-induced extracytoplasmic sigma factor E (SigE) of Mycobacterium tuberculosis shows increased expression after heat shock, sodium dodecyl sulfate treatment, and oxidative stress, as well as after phagocytosis in macrophages. We report that deletion of sigE results in delayed lethality in mice without a significant reduction of bacterial numbers in lungs.

PMID:
14638810
PMCID:
PMC308924
DOI:
10.1128/iai.71.12.7170-7172.2003
[Indexed for MEDLINE]
Free PMC Article

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