GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells

A F Lopez; M J Elliott; J Woodcock; M A Vadas

doi:10.1016/0167-5699(92)90025-3

GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells

Immunol Today. 1992 Dec;13(12):495-500. doi: 10.1016/0167-5699(92)90025-3.

Authors

A F Lopez¹, M J Elliott, J Woodcock, M A Vadas

Affiliation

¹ Hanson Centre for Cancer Research, Institute of Medical & Veterinary Science, Adelaide, Australia.

PMID: 1463582
DOI: 10.1016/0167-5699(92)90025-3

Abstract

The biological properties of GM-CSF, IL-3 and IL-5 are multiple; initially described as haemopoietic growth factors, they also regulate inflammation, allergic reactions and cell adherence. The receptors for these three cytokines share a common component which may play a key role in their biological activity. This review describes the potential roles of GM-CSF, IL-3 and IL-5 in inflammation and discusses approaches to modulate their function.

Publication types

Review

MeSH terms

Binding, Competitive
Cell Membrane / metabolism
Granulocyte-Macrophage Colony-Stimulating Factor / physiology*
Hematopoiesis
Humans
Inflammation / physiopathology
Interleukin-3 / physiology*
Interleukin-5 / physiology*
Leukocytes / physiology*
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / physiology*
Receptors, Immunologic / physiology*
Receptors, Interleukin*
Receptors, Interleukin-3 / physiology*
Receptors, Interleukin-5
Signal Transduction

Substances

Interleukin-3
Interleukin-5
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
Receptors, Immunologic
Receptors, Interleukin
Receptors, Interleukin-3
Receptors, Interleukin-5
Granulocyte-Macrophage Colony-Stimulating Factor