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Immunology. 2003 Oct;110(2):163-9.

The MHC class I antigen presentation pathway: strategies for viral immune evasion.

Author information

1
School of Biochemistry and Molecular Biology, University of Leeds, Leeds, UK. e.w.hewitt@leeds.ac.uk

Abstract

Presumably because of the selective pressure exerted by the immune system, many viruses have evolved proteins that interfere with antigen presentation by major histocompatibility complex (MHC) class I molecules. These viruses utilize a whole variety of ingenious strategies to inhibit the MHC class I pathway. Viral proteins have been characterized that exploit bottlenecks in the MHC class I pathway, such as peptide translocation by the transporter associated with antigen processing. Alternatively, viral proteins can cause the degradation or mislocalization of MHC class I molecules. This is often achieved by the subversion of the host cell's own protein degradation and trafficking pathways. As a consequence elucidation of how these viral proteins act to subvert host cell function will continue to give important insights not only into virus-host interactions but also the function and mechanism of cellular pathways.

PMID:
14511229
PMCID:
PMC1783040
DOI:
10.1046/j.1365-2567.2003.01738.x
[Indexed for MEDLINE]
Free PMC Article

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