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Anaesthesia. 2015 Dec;70(12):1441-52. doi: 10.1111/anae.13277.

A systematic review of sugammadex vs neostigmine for reversal of neuromuscular blockade.

Author information

1
Department of Anaesthesia, Hospital Universitario la Paz, Madrid, Spain.
2
Department of Anaesthesia, Complutense University of Madrid, Hospital Universitario Infanta Leonor, Madrid, Spain.
3
Department of Anaesthesia, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
4
Department of Anaesthesia, Örebro University Hospital, Örebro, Sweden.
5
Department of Consultant Preventive Medicine and Public Health, Complutense University of Madrid, Madrid, Spain.
6
Department of Colorectal Surgery, University of Zaragoza, Zaragoza, Spain.
7
Department of Anaesthesia, Complutense University of Madrid, Hospital Clínico San Carlos, Madrid, Spain.

Abstract

We reviewed systematically sugammadex vs neostigmine for reversing neuromuscular blockade. We included 17 randomised controlled trials with 1553 participants. Sugammadex reduced all signs of residual postoperative paralysis, relative risk (95% CI) 0.46 (0.29-0.71), p = 0.0004 and minor respiratory events, relative risk (95% CI) 0.51 (0.32-0.80), p = 0.0034. There was no difference in critical respiratory events, relative risk (95% CI) 0.13 (0.02-1.06), p = 0.06. Sugammadex reduced drug-related side-effects, relative risk (95% CI) 0.72 (0.54-0.95), p = 0.02. There was no difference in the rate of postoperative nausea or the rate of postoperative vomiting, relative risk (95% CI) 0.94 (0.79-1.13), p = 0.53, and 0.87 (0.65-1.17), p = 0.36 respectively.

PMID:
26558858
DOI:
10.1111/anae.13277
[Indexed for MEDLINE]
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