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Angew Chem Int Ed Engl. 2003 Sep 5;42(34):3996-4028.

Natural product hybrids as new leads for drug discovery.

Author information

1
Institut für Organische Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37 077 Göttingen, Germany. ltietze@gwdg.de

Abstract

Natural products play an important role in the development of drugs, especially for the treatment of infections and cancer, as well as immunosuppressive compounds. However, the number of natural products is limited, whereas millions of hybrids as combinations of parts of different natural products can be prepared. This new approach seems to be very promising in the development of leads for both medicinal and agrochemical applications, as the biological activity of several new hybrids exceeds that of the parent compounds. The advantage of this concept over a combinatorial chemistry approach is the high diversity and the inherent biological activity of the hybrids.

PMID:
12973759
DOI:
10.1002/anie.200200553
[Indexed for MEDLINE]

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