Format

Send to

Choose Destination
FEBS Lett. 2003 Sep 18;552(1):17-22.

Proton conduction through the M2 protein of the influenza A virus; a quantitative, mechanistic analysis of experimental data.

Author information

1
Johnson Research Foundation, Department of Biochemistry and Biophysics, School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104-6059, USA. lear@mail.med.upenn.edu

Abstract

The M2 proton channel from influenza A virus forms proton-selective ion channels, which are the target of the drug amantadine. Here, existing experimental data are quantitatively examined for insights into mechanisms to account for the pH- and voltage-dependences of M2 proton conduction. The analysis shows that a model involving protonation equilibria of His37, including pH-dependent changes in the relative rates of diffusion on either side of the pore, is quantitatively able to account for recently reported electrophysiological data examining the pH- and voltage-dependences of Rostock and Weybridge strain M2 proton conduction.

PMID:
12972146
DOI:
10.1016/s0014-5793(03)00778-6
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center