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J Virol. 2003 Apr;77(8):4992-9.

Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46.

Author information

1
Department of Microbiology, Osaka University Medical School, Suita, Osaka 565-0871, USA. ymori@micro.med.osaka-u.ac.jp

Abstract

Human CD46 is a cellular receptor for human herpesvirus 6 (HHV-6). Virus entry into host cells requires a glycoprotein H (gH)-glycoprotein L (gL) complex. We show that the CD46 ectodomain blocked HHV-6 infection and bound a complex of gH-gL and the 80-kDa U100 gene product, designated glycoprotein Q, indicating that the complex is a viral ligand for CD46.

PMID:
12663806
PMCID:
PMC152135
DOI:
10.1128/jvi.77.8.4992-4999.2003
[Indexed for MEDLINE]
Free PMC Article

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