Abstract
A new cancer cell growth inhibitory (P388 lymphocytic leukemia ED(50) 2.8 microg/mL) cyclodecapeptide designated phakellistatin 12 (2) has been isolated as a trace (1.7 x 10(-6)% yield) constituent of the Western Pacific Ocean (Federated States of Micronesia-Chuuk) sponge Phakellia sp. Employing principally a combination of high resolution FAB with high field (500 MHz) 1H, 13C and 2-D NMR and chiral GC analyses the structure (all S chirality) cyclo-Ile-Phe-Thr-Leu-Pro-Pro-Tyr-Ile-Pro-Pro was assigned.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Chromatography, Gas
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / isolation & purification
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Porifera / chemistry
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Spectrometry, Mass, Fast Atom Bombardment
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Stereoisomerism
Substances
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Antineoplastic Agents
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Peptides, Cyclic
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phakellistatin 12