Abstract
This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Aryldialkylphosphatase
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Carotid Stenosis / genetics
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Chromosome Mapping
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Chromosomes, Human, Pair 7
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Coronary Artery Disease / genetics
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Esterases / genetics*
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Ethnicity / genetics
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Genetic Predisposition to Disease / genetics
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Humans
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Inactivation, Metabolic / genetics
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Insecticides / metabolism*
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Insecticides / toxicity
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Linkage Disequilibrium
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Organophosphorus Compounds*
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Polymorphism, Genetic / genetics*
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Risk Factors
Substances
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Insecticides
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Organophosphorus Compounds
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Esterases
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Aryldialkylphosphatase
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PON1 protein, human