Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism

Annu Rev Med. 2003:54:371-92. doi: 10.1146/annurev.med.54.101601.152421. Epub 2001 Dec 3.

Abstract

This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Aryldialkylphosphatase
  • Carotid Stenosis / genetics
  • Chromosome Mapping
  • Chromosomes, Human, Pair 7
  • Coronary Artery Disease / genetics
  • Esterases / genetics*
  • Ethnicity / genetics
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Inactivation, Metabolic / genetics
  • Insecticides / metabolism*
  • Insecticides / toxicity
  • Linkage Disequilibrium
  • Organophosphorus Compounds*
  • Polymorphism, Genetic / genetics*
  • Risk Factors

Substances

  • Insecticides
  • Organophosphorus Compounds
  • Esterases
  • Aryldialkylphosphatase
  • PON1 protein, human