Format

Send to

Choose Destination
Pol Merkur Lekarski. 2002 Aug;13(74):126-8.

[Serum neopterin and beta2-microglobulin concentration as "prognostic markers" of AIDS].

[Article in Polish]

Author information

1
Klinika Chorób Zakaznych AM w Bydgoszczy.

Abstract

The aim of the study was evaluation of serum neopterin and beta 2-microglobulin concentrations as "prognostic markers" of AIDS natural history.

MATERIAL AND METHODS:

Investigations was performed in 68 patients (48 hiv-infected and 20 without hiv-infection), who were divided into 3 groups according to HIV CDC classification.

RESULTS:

The highest serum concentrations of neopterin and beta 2-microglobulin were detected in patients with AIDS. In a non-symptomatic HIV-infected patients p24 Ag was absent. It was detected in patients with AIDS. Negative correlation between neopterin and beta 2-microglobulin serum concentration and CD4 count was detected in sera from all patients. Positive correlation was observed between p24 Ag, serum neopterin and beta 2-microglobulin concentration in patients with AIDS.

CONCLUSIONS:

Progression of HIV infection was connected with an increase of serum neopterin and beta 2-microglobulin serum concentrations. Neopterin serum concentration seems to be a more sensitive marker of HIV infection than beta 2-microglobulin.

PMID:
12420343
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center