TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle

Diabetes Obes Metab. 2002 Nov;4(6):428-30. doi: 10.1046/j.1463-1326.2002.00227.x.

Abstract

Aim: We performed a case-control study to assess the association between obesity risk and the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene.

Methods: Obese subjects [n = 159; body mass index (BMI) > 30 kg/m2] and controls (n = 154; BMI < 25 kg/m2) were compared using multivariable logistic regression to control for potential confounders.

Results: A higher obesity risk (adjusted OR: 2.98; 95% CI: 1.00-8.56; p = 0.05) was associated with the Trp64Arg polymorphism among sedentary, but not among more active people.

Conclusions: Our results suggest that the TRP64ARG polymorphism of the ADRB3 seems to be a risk factor for obesity that is dependent on a sedentary lifestyle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Energy Metabolism
  • Exercise
  • Female
  • Humans
  • Life Style
  • Logistic Models
  • Male
  • Middle Aged
  • Mutation / genetics
  • Obesity / genetics*
  • Obesity / metabolism
  • Polymorphism, Genetic / genetics*
  • Receptors, Adrenergic, beta / genetics*
  • Regression Analysis
  • Risk Factors

Substances

  • Receptors, Adrenergic, beta