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Biomaterials. 2002 Dec;23(23):4609-14.

The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts.

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Graduate School of Biotechnology, Korea University, Sungbuk-Ku, Seoul, South Korea.


In this study, different molecular weight CM-chitosans were prepared and the effects on the growth and collagen secretion of normal skin fibroblasts and keloid fibroblasts were investigated in vitro. CM-chitosan promoted the proliferation of the normal skin fibroblast significantly but inhibited the proliferation of keloid fibroblast. The higher CM-chitosan concentration had a higher initial effect and the lower CM-chitosan concentration had a longer affecting time to the normal skin fibroblast. The lower molecular weight CM-chitosan had significant twofold activities. The CM-chitosan could reduce the ratio of type I/III collagen in keloid fibroblast by inhibiting the secretion of collagen type I; and had no effect on the secretion of types I and III collagen in the normal skin fibroblast.

[Indexed for MEDLINE]

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