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Acta Derm Venereol. 2001 Nov-Dec;81(6):403-5.

Tandem application of sodium lauryl sulfate and n-propanol does not lead to enhancement of cumulative skin irritation.

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Department of Dermatology, Friedrich-Schiller-University, Jena, Germany.


Irritant contact dermatitis has a broad spectrum of clinical features and is a leading cause of occupational disease worldwide. It has been shown previously that a combination of chemically different irritants may cause an additive effect compared to single application of these substances. In this study, tandem application of sodium lauryl sulfate and n-propanol was investigated in 20 human volunteers using non-invasive bioengineering methods, such as measurement of transepidermal water loss and chromametry. N-propanol did not enhance cumulative skin irritation when used with sodium lauryl sulfate, as has been reported for toluene. As n-propanol is the active ingredient in many disinfectants, this is of particular interest regarding occupational skin irritation in health care workers.

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