1. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):838-43. Epub 2002 Jan 15.

Life extension in Drosophila by feeding a drug.

Kang HL(1), Benzer S, Min KT.

Author information: 
(1)Neurogenetics Branch, MSC1250, 10/3B12, National Institute of Neurological
Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate
(PBA) can significantly increase lifespan, without diminution of locomotor vigor,
resistance to stress, or reproductive ability. Treatment for a limited period,
either early or late in adult life, is also effective. Flies fed PBA show a
global increase in histone acetylation as well as a dramatically altered pattern 
of gene expression, including induction or repression of numerous genes. The
delay in aging may result from the altered physiological state.

DOI: 10.1073/pnas.022631999 
PMCID: PMC117392
PMID: 11792861  [Indexed for MEDLINE]