Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):838-43. Epub 2002 Jan 15.

Life extension in Drosophila by feeding a drug.

Author information

1
Neurogenetics Branch, MSC1250, 10/3B12, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.

PMID:
11792861
PMCID:
PMC117392
DOI:
10.1073/pnas.022631999
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center