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J Chromatogr B Biomed Sci Appl. 2001 May 5;755(1-2):337-41.

High-performance liquid chromatographic assay of zonisamide in human plasma using a non-porous silica column.

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Department of Pharmacy, Gifu University Hospital, Japan.


A new method for measuring zonisamide (ZNS) in plasma by high-performance liquid chromatography was developed by using a 2-microm reversed-phase non-porous silica column. ZNS in plasma was first purified with a column extraction technique and injected onto the non-porous silica column. Calibration curve was linear over the concentration range of 1-80 microg/ml in plasma. The recoveries of ZNS added to plasma were more than 95.4% with the coefficient of variation less than 9.0%. We developed a rapid routine method using the non-porous silica column that was accurate and improved solvent consumption in the measurement of ZNS.

[Indexed for MEDLINE]

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