Abstract
The relative overexpression of estrogen receptor (ER)-alpha exon 5 splicing variant, the disrupted synchronization of ER-beta and ER-alpha expressions, and the suppression of progesterone receptor (PR) form A expression as a transcriptional repressor might be related to metastatic potential of uterine endometrial cancers, leading to poor patient prognosis related to estrogen refractoriness.
MeSH terms
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Alternative Splicing
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Animals
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Endometrial Neoplasms / genetics
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Endometrial Neoplasms / metabolism*
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Endometrial Neoplasms / secondary*
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Estrogen Receptor alpha
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Estrogen Receptor beta
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Female
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Gene Expression
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Humans
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Male
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Protein Isoforms / genetics
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Protein Isoforms / metabolism
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Rats
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Receptors, Estrogen / genetics
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Receptors, Estrogen / metabolism
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Receptors, Progesterone / genetics
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Receptors, Progesterone / metabolism
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Receptors, Steroid / genetics
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Receptors, Steroid / metabolism*
Substances
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Estrogen Receptor alpha
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Estrogen Receptor beta
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Protein Isoforms
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RNA, Messenger
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Receptors, Estrogen
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Receptors, Progesterone
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Receptors, Steroid