Steroid receptors and metastatic potential in endometrial cancers

J Steroid Biochem Mol Biol. 2000 Dec 31;75(4-5):209-12. doi: 10.1016/s0960-0760(00)00176-x.

Abstract

The relative overexpression of estrogen receptor (ER)-alpha exon 5 splicing variant, the disrupted synchronization of ER-beta and ER-alpha expressions, and the suppression of progesterone receptor (PR) form A expression as a transcriptional repressor might be related to metastatic potential of uterine endometrial cancers, leading to poor patient prognosis related to estrogen refractoriness.

Publication types

  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • Endometrial Neoplasms / genetics
  • Endometrial Neoplasms / metabolism*
  • Endometrial Neoplasms / secondary*
  • Estrogen Receptor alpha
  • Estrogen Receptor beta
  • Female
  • Gene Expression
  • Humans
  • Male
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Rats
  • Receptors, Estrogen / genetics
  • Receptors, Estrogen / metabolism
  • Receptors, Progesterone / genetics
  • Receptors, Progesterone / metabolism
  • Receptors, Steroid / genetics
  • Receptors, Steroid / metabolism*

Substances

  • Estrogen Receptor alpha
  • Estrogen Receptor beta
  • Protein Isoforms
  • RNA, Messenger
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Receptors, Steroid