Localization of G-protein-coupled receptors in health and disease

S W Edwards; C M Tan; L E Limbird

doi:10.1016/s0165-6147(00)01513-3

Localization of G-protein-coupled receptors in health and disease

Trends Pharmacol Sci. 2000 Aug;21(8):304-8. doi: 10.1016/s0165-6147(00)01513-3.

Authors

S W Edwards¹, C M Tan, L E Limbird

Affiliation

¹ National Center for Biotechnology Information, NLM, NIH, 8600 Rockville Pike, Room 8N805, Building 38A, Bethesda, MD 20894, USA. Edwards@ncbi.nlm.nih.gov

PMID: 10918636
DOI: 10.1016/s0165-6147(00)01513-3

Abstract

G-protein-coupled receptors (GPCRs) represent a superfamily of proteins, characterized by seven transmembrane alpha-helices, that signal through interactions with a family of heterotrimeric GTP-binding proteins, referred to as G proteins. The broad range of physiological functions associated with GPCRs indicates that a better understanding of these receptors and their regulation can provide a solid foundation for novel pharmacological interventions in a variety of disease states.

Publication types

Review

MeSH terms

Animals
Cell Membrane / chemistry
Cystic Fibrosis / etiology
Cystic Fibrosis Transmembrane Conductance Regulator / physiology
Diabetes Insipidus / etiology
GTP-Binding Proteins / physiology*
Humans
Hypercholesterolemia / etiology
Receptors, Cell Surface / analysis
Receptors, Cell Surface / chemistry
Receptors, Cell Surface / physiology*
Receptors, LDL / analysis
Retinitis Pigmentosa / etiology

Substances

CFTR protein, human
Receptors, Cell Surface
Receptors, LDL
Cystic Fibrosis Transmembrane Conductance Regulator
GTP-Binding Proteins