Abstract
We report six sibs with arthrogryposis multiplex congenita and a Pena-Shokeir phenotype, born to a healthy woman who was discovered to have asymptomatic myasthenia gravis (MG). This is the first report of anti-acetylcholine receptor (AChR) antibodies causing fetal akinesia/hypokinesia sequence in the offspring of an asymptomatic mother.
Copyright 2000 Wiley-Liss, Inc.
MeSH terms
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Abnormalities, Multiple / etiology
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Adult
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Arthrogryposis / etiology
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Autoantibodies / blood
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Child
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Child, Preschool
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Craniofacial Abnormalities / etiology*
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Craniofacial Abnormalities / genetics
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Family Health
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Female
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Fetal Death
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Humans
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Hypokinesia / etiology
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Male
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Myasthenia Gravis / complications*
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Pedigree
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Phenotype
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Pregnancy
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Pregnancy Complications
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Radioimmunoassay
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Receptors, Cholinergic / immunology
Substances
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Autoantibodies
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Receptors, Cholinergic