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Arthritis Rheum. 2000 Feb;43(2):365-9.

Detection of viral ribonucleic acid and histologic analysis of inflamed synovium in Ross River virus infection.

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1
University of Queensland, Townsville, Australia.

Abstract

OBJECTIVE:

To document the histology of Ross River virus (RRV) arthritis and to examine inflamed synovium for viral RNA.

METHODS:

Biopsy tissue from the inflamed knees of 12 patients with RRV infection was studied using conventional and immunostaining techniques. Reverse transcriptase-polymerase chain reaction technology was used to probe for the presence of viral RNA in the synovial biopsy samples and in serum.

RESULTS:

Hyperplasia of the synovial lining layer, vascular proliferation, and mononuclear cell infiltration were the main histologic changes. RRV RNA was found in knee biopsy tissue that was obtained from 2 patients at 5 weeks after the onset of symptoms.

CONCLUSION:

RRV RNA was identified in inflamed synovium more than a month after symptoms began. Inflammation was apparent in the absence of detectable virus in the majority of patients.

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