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J Am Acad Dermatol. 1999 Apr;40(4):590-6.

Experimentally induced chronic irritant contact dermatitis to evaluate the efficacy of protective creams in vivo.

Author information

1
Department of Dermatology, Friedrich-Schiller-University, Jena, Germany.

Abstract

BACKGROUND:

Widely accepted in vivo models to evaluate the efficacy of protective creams (PCs) are still missing.

OBJECTIVE:

The effect of petrolatum's ability to protect against irritation was tested in a repetitive irritation test to optimize the concentration of irritants against which PCs are tested and to evaluate the necessary cumulative application time.

METHODS:

On 20 healthy volunteers, the irritants (sodium lauryl sulfate 5% vs 10%, sodium hydroxide 0.5% vs 1%, lactic acid 20% vs 30%, and toluene undiluted) were applied daily for 2 weeks on the ventral forearms after 30 minutes of pretreatment with petrolatum. The irritant cutaneous reactions were quantified by erythema score, transepidermal water loss, and chromametry.

RESULTS:

For petrolatum, a significant protective effect was obtained against irritation by sodium lauryl sulfate, sodium hydroxide, and toluene in different degrees. Less efficacy was observed against lactic acid.

CONCLUSION:

It was concluded that a 1-week period of cumulative irritation is enough to evaluate the efficacy of PCs against most irritants, even if lower concentrations of irritants are used.

PMID:
10188679
DOI:
10.1016/s0190-9622(99)70442-1
[Indexed for MEDLINE]

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