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Arch Ophthalmol. 1999 Mar;117(3):329-39.

Basal linear deposit and large drusen are specific for early age-related maculopathy.

Author information

1
Department of Ophthalmology, University of Alabama at Birmingham, 35294-0009, USA. curcio@vision.vsrc.uab.edu

Abstract

OBJECTIVE:

To determine the distributions of basal laminar and basal linear deposits in Bruch membrane (BM) with respect to age and early age-related maculopathy (ARM).

METHODS:

The foveas of 41 human eyes (<60 years [n = 9]; > or =60 years [n = 32]), preserved no later than 3.5 hours post mortem, were examined using light and electron microscopy. Ten eyes met histopathologic criteria of the Alabama Age-related Macular Degeneration Grading System for early ARM. We calculated the specificity, sensitivity, and odds ratios for the association of basal laminar and basal linear deposits with early ARM.

RESULTS:

Both deposits occurred only in eyes older than 60 years. The highest specificities and sensitivities for early ARM were attained for eyes that had basal linear deposits or large (>125 microm) drusen, followed by eyes with any quantity of basal laminar deposits that also contained membranous debris. Eyes with ARM were 24 times more likely than age-matched control eyes to have basal linear deposits or large drusen (P = .002).

CONCLUSIONS:

Basal linear deposits and large drusen with membranous contents constitute different morphologic forms of the same ARM-associated lesion and may be significant for progression to late ARM.

PMID:
10088810
DOI:
10.1001/archopht.117.3.329
[Indexed for MEDLINE]

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