Absence of genetic variation in some obesity candidate genes (GLP1R, ASIP, MC4R, MC5R) among Pima indians

Int J Obes Relat Metab Disord. 1999 Feb;23(2):163-5. doi: 10.1038/sj.ijo.0800786.

Abstract

Objective: To examine the obesity candidate genes glucagon-like-peptide receptor (GLP1R), agouti signaling protein (ASIP) and the melanocortin receptors 4 and 5 (MC4R and MC5R) for DNA polymorphisms in their coding regions.

Subjects: Unrelated, non-diabetic Pima Indians (8 to 12 from each extreme of body fat).

Measurements: DNA sequencing within the coding regions of each gene.

Result: Only one variant was detected, a silent substitution in exon 6 of GLP1R.

Conclusion: The exclusion of any common amino-acid polymorphisms (allele frequency > or = 0.20). implies that structural variants of these genes do not contribute to variation in the high level of obesity observed among the Pima Indians.

MeSH terms

  • Agouti Signaling Protein
  • Arizona
  • Asian People / genetics*
  • Glucagon-Like Peptide-1 Receptor
  • Humans
  • Indians, North American / genetics*
  • Intercellular Signaling Peptides and Proteins*
  • Obesity / genetics*
  • Polymorphism, Genetic*
  • Proteins / genetics
  • Receptor, Melanocortin, Type 4
  • Receptors, Corticotropin / genetics
  • Receptors, Glucagon / genetics*
  • Receptors, Melanocortin
  • Receptors, Peptide / genetics

Substances

  • Agouti Signaling Protein
  • GLP1R protein, human
  • Glucagon-Like Peptide-1 Receptor
  • Intercellular Signaling Peptides and Proteins
  • Proteins
  • Receptor, Melanocortin, Type 4
  • Receptors, Corticotropin
  • Receptors, Glucagon
  • Receptors, Melanocortin
  • Receptors, Peptide
  • melanocortin 5 receptor