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Swiss Med Wkly. 2018 Dec 15;148:w14689. doi: 10.4414/smw.2018.14689. eCollection 2018 Dec 3.

Association of allostatic load with health-related quality of life in patients with arterial hypertension: a cross-sectional analysis.

Author information

1
Department of Medical Psychology and Psychotherapy, Medical University of Graz, Austria.
2
epartment of Medical Psychology and Psychotherapy, Medical University of Graz, Austria.
3
Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Austria.
4
Bad Gleichenberg Clinic, Bad Gleichenberg, Austria / Department of Internal Medicine, Division of Cardiology, Medical University of Graz, Austria.
5
Department of Medical Psychology and Psychotherapy, Medical University of Graz, Austria / Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Austria.

Abstract

AIMS OF THE STUDY:

Allostatic load (AL), as a marker of cumulative stress, is associated with higher morbidity and mortality, and reduced health-related quality of life (HrQoL) in healthy adults. In patients with hypertension, AL and its association with HrQoL have not been investigated. Therefore, this study aimed to (1) explore AL in a cohort of hypertensive patients and to (2) determine its association with HrQoL, while controlling for other health-related variables.

METHODS:

Cross-sectional data from the Styrian Hypertension Study were analysed and included 126 participants (50% female) with a history of arterial hypertension; the mean age was 60.9 years (standard deviation 9.9). AL was derived from a set of 10 biomarkers including neurophysiological, neuroendocrine, metabolic, cardiovascular and inflammatory parameters. The 36-Item Short Form Health Survey (SF-36) was administered for assessment of HrQoL. Additional health-related variables included sociodemographic data, lifestyle factors and comorbidities.

RESULTS:

Calculation of AL resulted in sum scores based on 10 binary variables, which were used to categorise patients as either “low AL” (<3) or “high AL” (≥3). Multivariate adjusted analyses revealed that higher AL was associated with better HrQoL with regard to the mental health domain F(1,1243) = 7.017; p = 0.009). All other components of HrQoL were not related to AL.

CONCLUSIONS:

In contrast to results in healthy populations, we found a positive association between AL and the mental health domain of HrQoL. This finding suggests a specific coping pattern among a subgroup of hypertensive patients, possibly influencing their clinical management and outcome.

PMID:
30552856
DOI:
10.4414/smw.2018.14689
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