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Med Gas Res. 2019 Jan 9;8(4):181-184. doi: 10.4103/2045-9912.248271. eCollection 2018 Oct-Dec.

Hyperbaric oxygen therapy for Alzheimer's dementia with positron emission tomography imaging: a case report.

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Department of Medicine, Section of Emergency and Hyperbaric Medicine, Louisiana State University School of Medicine, New Orleans, LA, USA.
Department of Radiology, University of North Dakota School of Medicine and Health Sciences, Bismarck, ND, USA.


A 58-year-old female was diagnosed with Alzheimer's dementia (AD) which was rapidly progressive in the 8 months prior to initiation of hyperbaric oxygen therapy (HBOT). 18Fluorodeoxyglucose (18FDG) positron emission tomography (PET) brain imaging demonstrated global and typical metabolic deficits in AD (posterior temporal-parietal watershed and cingulate areas). An 8-week course of HBOT reversed the patient's symptomatic decline. Repeat PET imaging demonstrated a corresponding 6.5-38% regional and global increase in brain metabolism, including increased metabolism in the typical AD diagnostic areas of the brain. Continued HBOT in conjunction with standard pharmacotherapy maintained the patient's symptomatic level of function over an ensuing 22 months. This is the first reported case of simultaneous HBOT-induced symptomatic and 18FDG PET documented improvement of brain metabolism in AD and suggests an effect on global pathology in AD.


Alzheimer's dementia; hyperbaric oxygen; imaging pharmacokinetics; positron emission tomography; pressure pharmacodynamics; textural analysis

Conflict of interest statement

Conflicts of interest PGH is co-owner of a company that does consulting and renders expert opinions in hyperbaric medicine. EFF is vice-president of the International Hyperbaric Medical Foundation (IHMF), a non-profit corporation that promotes education, research, and teaching in hyperbaric medicine. He derives no income from the IHMF. He also owns a holding company for a mobile hyperbaric clinic named MoPlatte Hyperbarics, LLC.

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